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The compound is cumulative in action and will require several weeks to exert its beneficial therapeutic effectswhereas minor side effects may occur relatively earlySeveral months of therapy may be required before maximum effects can be obtainedIf objective improvementsuch as reduced joint swellingincreased mobilitydoes not occur within six monthsthe drug should be discontinuedSafe use of the drug in the treatment of juvenile rheumatoid arthritis has not been established.

Suicidal behavior has been reported in very rare cases in patients treated with hydroxychloroquine.

Use of PLAQUENIL in patients with psoriasis may precipitate a severe attack of psoriasisWhen used in patientswith porphyria the condition may be exacerbatedThe preparation should not be used in these conditions unless in the judgment of the physician the benefit to the patient outweighs the possible hazard.

Inform your doctor if your condition persists or worsensIt may take several weeks or months to see improvement if you are taking this for lupus or arthritisHydroxychloroquine may not prevent malaria in all casesIf you experience fever or other symptoms of illnessseek immediate medical attentionYou may need a different medicationAvoid exposure to mosquitoesSee also Notes section.

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