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A 3-month, randomized, double-blind, placebo-controlled study was performed to assess the neurocognitive and behavioral effects of keppra as adjunctive therapy in 98 keppra n 64, placebo n 34 pediatric patients, ages 4 to 16 years old, with partialseizures that were inadequately controlled.

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In additionthe following adverse reactions were seen in other controlled adult studies of KEPPRAbalance disorderdisturbance in attentioneczemamemory impairmentmyalgiaand blurred vision.

This study was too small to adequately characterize the adverse reactions that could be expected to result in discontinuation of treatment in this populationIt is expected that the adverse reactions that would lead to discontinuation in this population would be similar to those resulting . in discontinuation in other epilepsy trialssee tables 4 and 8

Dosing adjustment for adult and adolescents patients weighing more than 50 kg with impaired renal function:

The use of levetiracetam has been very rarely associated with acute kidney injurywith a time to onset ranging from a few days to several months.

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