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Metronidazole has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulantsresulting in a prolongation of prothrombin timeWhen FLAGYL is prescribed for patients on this type of anticoagulant therapyprothrombin time and INR should be carefully monitored.
When repeat courses of the drug are requiredit is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measuresTotal and differential leukocyte counts should be made before and after re-treatment.
Following a single intravenous infusion or oral dose of metronidazole 500 mgthe clearance of metronidazole was investigated in ESRD subjects undergoing hemodialysis or continuous ambulatory peritoneal dialysisCAPDA hemodialysis session lasting for 4 to 8 hours removed 40to 65of the administered metronidazole dosedepending on the type of dialyzer membrane used and the duration of the dialysis sessionIf the administration of metronidazole cannot be separated from the dialysis sessionsupplementation of metronidazole dose following hemodialysis should be consideredsee DOSAGE AND ADMINISTRATIONA peritoneal dialysis session lasting for 7.5 hours removed approximately 10of the administered metronidazole doseNo adjustment in metronidazole dose is needed in ESRD patients undergoing CAPD.
The way to take this medicineOral Store below 30 degrees Celsius Protect from Light Lifetime is 3 Years.
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