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This drug is known to be substantially excreted by the kidneyand the risk of toxic reactions to this drug may be greater in patients with impaired renal functionBecause elderly patients are more likely to have decreased renal functioncare should be taken in dose selectionand dose should be adjusted based on creatinine clearance values in these patientssee DOSAGE AND ADMINISTRATIONADVERSE REACTIONSand CLINICAL PHARMACOLOGY
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