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Nauseavomitingloss of appetitestomach achediarrheaor darkening of the skin/nails may occurNausea and vomiting can be severeIn some casesdrug therapy may be necessary to prevent or relieve nausea and vomitingChanges in diet such as eating several small meals or limiting activity may help lessen some of these effectsIf these effects persist or worsennotify your doctor or pharmacist promptly.
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Hepatic imparimentGive 75of normal dose if transaminase levels are3 times upper limit of normal or bilirubin is 3.1-5 mg/dL.
Secondary malignanciesUrinary bladdermyeloproliferativelymphoproliferative.
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