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Approximately 15of patients who had atrial flutter/fibrillation and received this drug and digoxin developed resting ventricular rates below 50 beats/minin the same trialasymptomatic hypotension occurred in approximately 5of patients.
Electrical activity through the AV node dependsto a significant degreeupon calcium influx through the slow channelBy decreasing the influx of calciumISOPTIN prolongs the effective refractory period within the AV node and slows AV . conduction in a rate related manner.
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