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Administration with food has no effect on the rate or extent of colchicine absorptionColchicine is not effectively removed by hemodialysis.
Myelosuppressionleukopeniagranulocytopeniathrombocytopeniapancytopeniaand aplastic anemia havebeen reported with colchicine used in therapeutic doses.
If you are taking this medication to treat symptoms due to familial Mediterranean fevertell your doctor if your condition does not improve or if it worsens.
Fatal overdosesboth accidental and intentionalhave been reported in adults and children who have ingested colchicineSee OVERDOSEColchicine capsules should be kept out of the reach of children.
In a published study in healthy volunteers40 to 65of the total absorbed dose of colchicine1 mg administered orallywas recovered unchanged in urineEnterohepatic recirculation and biliary excretion are also believed to play a role in colchicine eliminationColchicine is a substrate of P-gp and P-gp efflux is postulated to play an important role in colchicine dispositionElimination half-life in humans was found to be 31 hrange 21.7 to 49.9 h
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