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Drinking alcohol can further lower your blood pressure and may increase certain side effects of valsartan.

In children and adolescents with hypertension where underlying renal abnormalities may be more commonrenal function and serum potassium should be closely monitored as clinically indicated.

Valsartanwhen administered as an oral solutionis primarily recovered in fecesabout 83of doseand urineabout 13of doseThe . recovery is mainly as unchanged drugwith only about 20of dose recovered as metabolitesThe primary metaboliteaccounting for about 9of doseis valeryl 4-hydroxy valsartanIn vitro metabolism studies involving recombinant CYP 450 enzymes indicated that the CYP 2C9 isoenzyme is responsible for the formation of valeryl-4-hydroxy valsartanValsartan does not inhibit CYP 450 isozymes at clinically relevant concentrationsCYP 450 mediated drug interaction between valsartan and coadministered drugs are unlikely because of the low extent of metabolism.

Do not take Diovan after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.

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