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If you are wearing contact lensesremove them before using this medicationWait at least 15 minutes before replacing your contact lenses.

Advise patientsthat if they develop an intercurrent ocular conditione.gtrauma or infectionor have ocular surgeryor develop any ocular reactionsparticularly conjunctivitis and eyelid reactionsthey should immediately seek their physician’s advice concerning the continued use of the multiple-dose container.

UseReduction of elevated intraocular pressureIOPin patients with open-angle glaucoma or ocular hypertension.

METHODSThis multicenterrandomizedinvestigator-maskedparallel-group study allocated 266 patients with . OH or POAG in a 1:1 ratio to latanoprost or Xalatan administered once daily for 6 weeksThe primary endpoint was the mean change in 8:00 AM IOP of the study eye from baseline to week 6Secondary endpoints included mean change in 8:00 AM IOP from baseline to week 2and in 12:00 noon and 4:00 PM IOP from baseline to week 2 and week 6The safety and tolerability of both drugs were also assessed.

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