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Information about Coumadin
But the tablet shape may be differentlike oval or squareif you change brands.
The intravenous dose of COUMADIN is the same as the oral doseAfter reconstitutionadminister COUMADIN for injection as a slow bolus injection into a peripheral vein over 1 to 2 minutes.
COUMADIN has a narrow therapeutic rangeindexand its action may be affected by factors such as other drugs and dietary vitamin KThereforeanticoagulation must be carefully monitored during COUMADIN therapyDetermine the INR daily after the administration of the initial dose until INR results stabilize in the therapeutic rangeAfter stabilizationmaintain dosing within the therapeutic range by performing periodic INRsThe frequency of performing INR should be based on the clinical situation but generally . acceptable intervals for INR determinations are 1 to 4 weeksPerform additional INR tests when other warfarin products are interchanged with COUMADINas well as whenever other medications are initiateddiscontinuedor taken irregularlyHeparina common concomitant drugincreases the INRsee Conversion From Other Anticoagulants and DRUG INTERACTIONS
Select the initial dose based on the expected maintenance dosetaking into account the above factorsModify this dose based on consideration of patient-specific clinical factorsConsider lower initial and maintenance doses for elderly and/or debilitated patients and in Asian patientssee Use In Specific Populations and CLINICAL PHARMACOLOGYRoutine use of loading doses is not recommended as this practice may increase hemorrhagic and other complications and does not offer more rapid protection against clot formation.
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