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AlsoSNRIs often have less bothersome side effects than tricyclic antidepressantssuch as amitriptylinewhich are sometimes prescribed to those with fibromyalgia.

SSRIs and SNRIs may impair platelet aggregation and increase the risk of bleeding eventsranging from ecchymoseshematomasepistaxispetechiaeand GI hemorrhage to life-threatening hemorrhageconcomitant use of aspirinNSAIDswarfarinother anticoagulantsor other drugs known to affect platelet function may add to this risk.

Jay WMarksMDis a board-certified internist and gastroenterologistHe graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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