Such drugs include dicyclomine bentyl , some antihistamines for example, carbinoxamine rondec , clemastine tavist , diphenhydramine benadryl , promethazine phenergan ; some phenothiazines for example, thioridazine mellaril , triflupromazine stelazine ; some tricyclic antidepressants for example, amitriptyline elavil, endep amoxapine asendin , clomipramine anafranil , protriptyline vivactil ; clozapine clozaril , cyclobenzaprine flexeril , and disopyramide norpace .
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The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythmBefore using clozapinetell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death
With schizophrenia who are non-responsive to or intolerant of antipsychotic medicationor with psychosis in Parkinson’s disease when other treatment strategies have failedsee section 4.1
Clozapine is associated with an increased risk of myocarditis which hasin rare casesbeen fatalThe increased risk of myocarditis is greatest in the first 2 months of treatmentFatal cases of cardiomyopathy have also been reported rarelysee section 4.4
Clozapine can cause low blood pressure or a slow heartbeatwhich can make you dizzy or cause you to faint when you stand upThe risk is higher when you first start or increase your dose of medicationDizziness and lightheadedness can increase the risk of fallingGet up slowly when rising from a sitting or lying position.
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