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Selegiline is indicated for the treatment of Parkinson’s disease whichin most casesis a disease occurring after childbearing age.
The available safety data concerning the use during pregnancy and lactation is insufficient to justify the use of selegiline in these patient groups.
Parkinson’s disease patients treated with dopamine agonists and other dopaminergic treatments have been reported as exhibiting impulse control disorders and compulsions like pathological gamblingincreased libidohypersexualitybinge eatingshopping and different kinds of compulsive/repetitive activitiespundingThese may also be possible with selegiline but very few cases have been reported to date.
Concomitant administration of amantadine and anticholinergic drugs can lead to an increased occurrence of side-effects.
In view of the high degree of binding to plasma proteins by selegiline particular attention must be given to patients who are being treated with . medicines with a narrow therapeutic marginindexsuch as digitalis and/or anticoagulants.
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