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By 1997, one year later, precose csir realized that the ingredient, p57 was responsible for the weight loss precose in hoodia gordonii.

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Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119a potential drug target for metabolic disorder.

Obesity is one of the most common health concerns todayHerbal-based food supplements are widely used to treat obesityAmong themthe African cactiform Hoodia gordonii supplements are extremely popularThe development of Hoodia and P57the purported active ingredienthas been problematic due to controversy about intellectual property rights and limited natural resourcesTo datethe true active components and molecular targets of Hoodia remain unclearHerewe demonstrate that Gordonoside Fa compound from Hoodiaactivates GPR119a receptor critically involved in metabolic homeostasisand leads to increased insulin secretion and reduced food intakeThe successful synthesis of Gordonoside F described here will provide an opportunity for developing new drugs in treating metabolic diseases.

Almost ninety percent of Hoodia Gordonii users are of the belief that it has no side effects at all on the bodywhich is true to some extentbut not absolutelyThere are two reasons behind thisThe first one is that its side effects do not show up or are not detected quicklyunlike caffeine in green tea and other stimulants found in other appetite suppressantsSecondeven if some people know about itthey tend to ignore it and are just overwhelmed by the weight reducing effects of hoodia and the fact that it is in such high fashion todayYou take it and you fall in the same line with Britney Spears!

Hoodia Gordonii is a true gift of nature that promotes weight lossBeing overweight and obeseas well as having diabetes and related problemshas taken over the world like a disastrous epidemic over the last few decades and people are ready to do just about anything to get rid of these problemsThis started an endless search for natural productssynthetic medicinesand diet plans that could help people lose weightIt is one of the most promising finds in this endless search.

The plant is a tiny cactus-like succulent called hoodia gordoniione of a dozen hoodia species growing in NamibiaAngola and South AfricaThe Bushmen have long nibbled on this plant to suppress their appetite during long days of hunting for food.

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