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There have been postmarketing reports of serious skin/hypersensitivity reactionse.gStevens-Johnson Syndrometoxic epidermal necrolysiserythema multiformeexfoliative dermatitisbullous dermatitisand drug reaction with eosinophilia and systemic symptomsDRESSsyndromeManifestations of DRESS syndrome may include cutaneous reactionsuch as rash or exfoliative dermatitiseosinophiliaand one or more organ complications such as hepatitispneumonitisnephritismyocarditisand pericarditisIf progressive skin rash or signs/symptoms of the above drug reactions occurtreatment with Lamisil Tablets should be discontinued.
Pretreatment serum transaminase alt and ast tests are advised for all patients before taking lamisil oral granules terbinafine hydrochloride
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Terbinafinean allylamine antifungalinhibits biosynthesis of ergosterolan essential component of fungal cell membranevia inhibition of squalene epoxidase enzymeThis results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not dueto ergosterol deficiencyDepending on the concentration of the drug and the fungal species test in vitroterbinafine hydrochloride may be fungicidalHoweverthe clinical significance of in vitro data is unknown.
Other drugs may interact with terbinafineincluding prescription and over-the-counter medicinesvitaminsand herbal productsTell each of your health care providers about all medicines you use now and any medicine you start or stop using.
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