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The rationale for this treatment schedule is based on two major premisesathe anti-inflammatory or therapeutic effect of corticoids persists longer than their physical presence and metabolic effects andbadministration of the corticosteroid every other morning allows for re-establishment of more nearly normal hypothalamic-pituitary-adrenalHPAactivity on the off-steroid day.

For people with infectionsTaking prednisone weakens your immune system and can worsen an infection you already haveIt also increases your risk of getting a new infection.

For people with diabetesPrednisone can increase your blood sugar levelYou might need to monitor your blood sugar level more closelyIf it goes up too muchyour dosage of diabetes medication might need to be changed.

An overdose of prednisone is not expected to produce life threatening symptomsHoweverlong term use of high steroid doses can lead to symptoms such as thinning skineasy bruisingchanges in the shape or location of body fatespecially in your faceneckbackand waistincreased acne or facial hairmenstrual problemsimpotenceor loss of interest in sex.

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