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There is no indication for the use of EVISTA in menEVISTA has not been adequately studied in men and its use is not recommended.
The drugRaloxifene is a benzothiophene compound taken orally once a dayIt undergoes significant first-pass metabolism to glucuronide conjugatesNinety-five percent of the drug circulates protein-boundand it is mostly excreted in the fecesAs with estrogenraloxifene’s effects occur when the drug binds tightly to estrogen receptorswhich alters gene transcription in susceptible cellsRaloxifene’s bone effects appear to be mediated through osteoblastswhich results in the promotion of bone deposition in a manner similar to that of estrogenrather than the osteoclast inhibition seen with other therapies such as bisphosphonatesRaloxifene is less effective than estrogen at promoting bone deposition but is more effective than placebo at increasing bone mineral densityand it is used to both treat and prevent osteoporosis in postmenopausal women.
Raloxifene is an estrogen agonist/antagonistcommonly referred to as a selective estrogen receptor modulatorSERMThe biological actions of raloxifene are largely mediated through binding to estrogen receptorsThis binding results in activation of estrogenic pathways in some tissuesagonismand blockade of estrogenic pathways in othersantagonismThe agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptorERtarget gene promoters.
EVISTA is indicated for the treatment and prevention of osteoporosis in postmenopausal womensee Clinical Studies
Symptoms of a broken bone include pain at the site of injuryswellingand bruising around the area of injuryTreatment of a fracturedepends on the type and location of the injury.
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