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In womenlong-term levothyroxine sodium therapy has been associated with increased bone resorptionthereby decreasing bone mineral densityespecially in post-menopausal women on greater than replacement doses or in women who are receiving suppressive doses of levothyroxine sodiumThe increased bone resorption may be associated with increased serum levels and urinary excretion of calcium and phosphorouselevations in bone alkaline phosphatase and suppressed serum parathyroid hormone levelsThereforeit is recommended that patients receiving levothyroxine sodium be given the minimum dose necessary to achieve the desired clinical and biochemical response.
Common side effects of levothyroxine include tremorschange in appetiteand irregular heartbeats.
Partial hair loss may occurrarely during the first few months of levothyroxine therapybut this is usually temporary.
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