In the anastrozole adjuvant trial, co-administration of anastrozole and nolvadex in breast cancer patients reduced anastrozole plasma concentration by 27 compared to those achieved with anastrozole alone; however, the coadministration did not affect the pharmacokinetics of tamoxifen or n-desmethyltamoxifen see precautions -drug interactions .
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QI have to make a decision on taking tamoxifen and I am concerned about the side effects of blood clotsvision and other cancersI am not sure the risks are worth the risks of changing the quality of my life if I suffer with side effectsMy system is very sensitive to drugs in general.
If you have headacheslet your doctor or nurse knowThey can usually be controlled with mild painkillers.
Taking tamoxifen . may increase your risk of uterine cancerstrokeor a blood clot in the lungwhich can be fatalTalk with your doctor about your specific risks in taking this medication.
Talk to your doctor about these risksand notify him if you have any unusual problems while taking this medication.
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