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ZETIA reduces total-CLDL-CApo Bnon-HDL-Cand TGand increases HDL-C in patients with hyperlipidemiaAdministration of ZETIA with a statin is effective in improving serum total-CLDL-CApo Bnon-HDL-CTGand HDL-C beyond either treatment aloneAdministration of ZETIA with fenofibrate . is effective in improving serum total-CLDL-CApo Band non-HDL-C in patients with mixed hyperlipidemia as compared to either treatment aloneThe effects of ezetimibe given either alone or in addition to a statin or fenofibrate on cardiovascular morbidity and mortality have not been established.

Unusual muscle weaknesstendernessor painnauseastomach painlow feverloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyeschestpainpancreatitissevere pain in your upper stomach spreading to your backnausea and vomitingfast heart rateor feversore throat.

All of the clinical studies that have been performed are limited to primary hypercholesterolemiaPrimary hypercholesterolemia is due to a genetic defect in cholesterol metabolismwhereas secondary hypercholesterolemia is due to secondary factors such as obesitydiabetes mellitusphysical inactivityandor nutritionUnfortunatelythere are no data to support the use of ezetimibe in patients with secondary hypercholesterolemiaThereforethe findings of these trialssome of which are summarized hereapply only to those patients with primary hypercholesterolemia.

Concurrent administration of ZETIA with a specific statin or fenofibrate should be in accordance with the product labeling for that medication.

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