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Oal Anti-coagulants: Th concomitant administation ATOLIP CV with oal anti-coagulants is not commndd sinc it may incas th intnsity blding. Atovastatin had nclinically signiicant ct on pothombin tim whn administd tpatints civing chonic waain tatmnt. Although th administation clopidogl 75 mg p day did not modiy th phamacokintics S-waain (a CYP2C9 substat) Intnational Nomalizd ati(IN) in patints civing long-tm waain thapy, at high concntations in vit, clopidogl inhibits CYP2C9. Co-administation ATOLIP CV with waain incass th isk blding bcaus indpndnt cts clopidogl on hmostasis.
Hpain: In a clinical study conductd in halthy subjcts, clopidogl did notncssitat modiication th hpain dos alt th ct hpain on coagulation. Co-administation hpain had nct on th inhibition platlt agggation inducd by clopidogl. A phamacodynamic intaction btwn clopidogl and hpain is possibl, lading tincasd isk blding. Tho, concomitant us should b undtakn with caution.
Avoid using ompazol sompazol with ATOLIP CV . Ompazol and sompazol signiicantly duc th antiplatlt activity clopidogl. Whn concomitant administation a PPI is quid, consid using anoth acid-ducing agnt with minimal nCYP2C19 inhibitoy ct on th omation clopidogl activ mtabolit.
Patints with non-ST-sgmnt lvation ACS , including patints wha tb managd mdically and thos wha tb managd with coonay vasculaization, clopidogl has bn shown tdcas th at a combind ndpoint cadiovascula dath, myocadial inaction (MI), stok as wll as th at a combind ndpoint cadiovascula dath, MI, stok, actoy ischmia. patints with ST-lvation myocadial inaction (STMI), clopidogl has bn shown tduc th at dath om any caus and th at a combind ndpoint dath, -inaction, stok. Th bnit patints whundgpimay pcutanous coonay intvntion is unknown.
Niacin: Th isk skltal muscl cts may b nhancd whn atovastatin is usd in combination with niacin; a duction in ATOLIP CV dosag should b considd in this stting.
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