Inhibition of dog gastric lipase dgl by mixed 1,2-dicaprin orlistat films is reversible.
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Because XENICAL has been shown to reduce the absorption of some fat-soluble vitamins and betacarotenepatients should be counseled to take a multivitamin containing fat-soluble vitamins to ensure adequate nutritionsee WARNINGS AND PRECAUTIONSThe vitamin supplement should be taken at least 2 hours before or after the administration of XENICALsuch as at bedtime.
The dose-response relationship for orlistat in human volunteers is shown in Figure 1The effect is the percentage of ingested fat excretedreferred to as fecal fat excretion percentageBoth individual dataopen circlesand the curve predicted for the population with the maximum-effect modelcontinuous lineare shown in Figure 1.
The long-term effects of XENICAL on morbidity and mortality associated with obesity have not been established.
Data from a XENICAL and cyclosporine drug interaction study indicate a reduction in cyclosporine plasma levels when XENICAL was coadministered with cyclosporineXENICAL and cyclosporine should not be simultaneously coadministeredCyclosporine should be administered 3 hours after the administration of XENICALsee DOSAGE AND ADMINISTRATIONand WARNINGS AND PRECAUTIONS
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