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Other medications which also may be effective include neurontin gabapentin and the long-acting version called horizant.

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Anyone considering prescribing NEURONTIN or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illnessEpilepsy and many other illnesses for which AEDs areprescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behaviorShould suicidal thoughts and behavior emerge during treatmentthe prescriber needs to consider whether the emergence of these symptoms in any given patient may be related to the illness being treated.

Gabapentin did not demonstrate mutagenic or genotoxic potential in three in vitro and four in vivo assaysIt was negative in the Ames test and the in vitro HGPRT forward mutation assay in Chinese hamster lung cellsit did not produce significant increases in chromosomal aberrations in the in vitro Chinese hamster lung cell assayit was negative in the in vivo chromosomal aberration assay and in the in vivo micronucleus test in Chinese hamster bone marrowit was negative in the in vivo mouse micronucleus assayand it did not induce unscheduled DNA synthesis in hepatocytes from rats given gabapentin.

Report any new or worsening symptoms to your doctorsuch asmood orbehavior changesanxietypanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallydepressedor have thoughts about suicide or hurting yourself.

The increased risk of suicidal thoughts or behavior with AEDs was observed as early as one week after starting drug treatment with AEDs and persisted for the duration of treatment assessedBecause most trials included in the analysis did not extend beyond 24 weeksthe risk of suicidal thoughts or behavior beyond 24 weeks could not be assessed.

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