If you have liver or kidney disease and you are also taking colchicine.
Information about Colchicine.
Tell your doctor and pharmacist if you are allergic to colchicineany other medicationsor any of the ingredients in colchicine tabletsAsk your doctor or pharmacist or check the medication guide for a list of ingredientstell your doctor and pharmacist what prescription and nonprescription medicationsvitaminsnutritional productsand herbal supplements you are takinghave taken within the past 14 daysor plan to takeBe sure to mention any of the followingantibiotics such as azithromycinZithromaxclarithromycinBiaxinand erythromycinE.E.SE-MycintelithromycinKetekantifungals such as fluconazoleDiflucanitraconazoleSporanoxand ketoconazoleNizoralaprepitantEmendcholesterol-lowering medicationsstatinssuch as atorvastatinLipitorfluvastatinLescollovastatinMevacorpravastatinPravacholand simvastatinZocorcyclosporineGenGrafNeoralSandimmunedigoxinDigitekLanoxindiltiazemCardizemDilacorTiazacothersfibrates such as bezafibratefenofibrateAntaraLipofenand gemfibrozilLopidmedications for HIV or AIDS such as amprenavirAgeneraseatazanavirReyatazfosamprenavirLexivaindinavirCrixivannelfinavirViraceptritonavirin KaletraNorvirand saquinavirInvirasenefazodoneranolazineRanexaand verapamilCalanCoveraIsoptinVerelanYour doctor may need to change the doses of your medications or monitor you carefully for side effects tell your doctor if you have or have ever had kidneyor liver diseasetell your doctor if you are pregnantplan to become pregnantor are breast-feedingIf you become pregnant while taking colchicinecall your doctor.
Published studies demonstrated that colchicine was negative for mutagenicity in the bacterial reverse mutation assayHoweverin vitro chromosomal aberration assays demonstrated the formation of micronuclei following colchicine treatmentBecause published studies demonstrated that colchicine induces aneuploidy through the process of mitotic nondisjunction without structural DNA changescolchicine is not considered clastogenicalthough micronuclei are formed.
Antifungal drugssuch as ketoconazole or itraconazoleUsing these drugs with colchicine can result in very high levels of colchicine in your bodyThis raises your risk of side effectssuch as severe muscle damageHIV drugssuch as indinaviratazanavirnelfinavirsaquinaviror ritonavirUsing these drugs with colchicine can result in very high levels of colchicine in your bodyThis raises your risk of side effectssuch as severe muscle damageAntibioticssuch as clarithromycin or telithromycinUsing these drugs with colchicine can result in very high levels of colchicine in your bodyThis raises your risk of side effectssuch as severe muscle damageAntidepressantssuch as nefazodoneUsing these drugs with colchicine can resultin very high levels of colchicine in your bodyThis raises your risk of side effectssuch as severe muscle damage.
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