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Elavil amitriptyline exerts its antidepressant action principally from inhibiting the reuptake of the neurotransmitters serotonin and, to a lesser extent, norepinephrine, thereby boosting neurotransmission in the central nervous system.

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Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neuronsPharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activityThis interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Before taking Elaviltell your doctor if you have used anSSRIantidepressant in the past 5 weekssuch as citalopramCelexaescitalopramLexaprofluoxetineProzacSarafemSymbyaxfluvoxamineLuvoxparoxetinePaxilor sertralineZoloft

For PainI was given this medication to help my daily chronic headachesStarted it a little over a month agoThree days in I had one of the worst headaches everAfter that the headaches started to diminishI now have weakness and loss of feeling in my hands arms and legs and feetseizure activityconfusionand sleeping all the timeI don’t feel like myself and I’m super miserable all the timeDr doesn’t want to take me off this medication but I cannot live life like thisI don’t recommend this medication

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