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Boehringer lngelhe im notifies health professionals about the potential effect that viramune nevirapine may have in patients taking chron ic methadone maintenance.

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It is not recommended to co-administer efavirenz and Viramunesee section 4.4because of additive toxicity and no benefit in terms of efficacy over either NNRTI alonefor results of 2NN studysee section 5.1

Because of the risk of increased exposure to Viramunecaution should be exercised if the medicinal products are given concomitantly and patients should be monitored closely.

Indicated . for treatment of HIV-1 infection in combination with other antiretrovirals.

It is not recommended to coadminister boceprevir and Viramunesee section 4.4

The concomitant administration of Viramune with NNRTIs is not recommendedsee section 4.4

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