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Leukopenia Thrombocytopenia Tumor cell infiltration of bone marrow Previous X-ray therapy Previous therapy with other cytotoxic agents Impaired hepatic function Impaired renal function.
The physician should be alert for possible combined drug actionsdesirable or undesirableinvolving cyclophosphamide even though cyclophosphamide has been used successfully concurrently with other drugsincluding other cytotoxic drugs.
MetronidazoleAcute encephalopathy has been reported in a patient receiving cyclophosphamide and metronidazoleCausal association is unclearIn an animal studythe combination of cyclophosphamide with metronidazole was associated with increased cyclophosphamide toxicity.
The following adverse reactions are discussed in more detail in other sections of the labeling.
Granulomatosis with polyangiitissevere rheumatoid arthritislupus erythematosusadvanced mycosis fungoidesand several of forms of vasculitis.
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