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The efficacy of the extended-release tablets for the maintenance treatment of MDD has not been evaluatedWhile there is no body of evidence available to answer the question of how long a patient treated with trazodone extended-release tablets should continue the drugit is generally recommended that treatment be continued for several months after an initial responsePatients should . be maintained on the lowest effective dose and be periodically reassessed to determine the continued need for maintenance treatment.

Lung problems or other complications in the baby may arise if you are taking this medication while pregnantThere is risk of depression relapse if you stop taking your antidepressantTell your doctor right away if you become pregnant while taking TrazodoneDo not start or stop taking this medicine during pregnancy without consulting your doctor.

In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitorsRitonavira potent CYP3A4 inhibitorincreased the C maxAUCand elimination half-lifeand decreased clearance of trazodone after administration of ritonavir twice daily for 2 daysAdverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administeredIt is likely that ketoconazoleindinavirand other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrationswith the potential for adverse effectsIf trazodone is used with a potent CYP3A4 inhibitora lower dose of trazodone should be considered.

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