Commonly observed in patients with spasticity of spinal origin in pre- and post- marketing clinical trials, the most commonly observed adverse events associated with use of lioresal intrathecal baclofen injection which were not seen at an equivalent incidence among placebo-treated patients were somnolence, dizziness, nausea, hypotension, headache, convulsions and hypotonia.
Information about Lioresal
Lioresal is also indicated in adults and children for the relief of spasticity of voluntary muscle arising from . e.gcerebrovascular accidentscerebral palsymeningitistraumatic head injury.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relieverssuch as codeinehydrocodonealcoholmarijuanadrugs for sleep or anxietysuch as alprazolamlorazepamzolpidemother muscle relaxantssuch as carisoprodolcyclobenzaprineor antihistaminessuch as cetirizinediphenhydramine
The determination of optimal dosage requires individual titrationStart therapy at a low dosage and increase gradually until optimum effect is achievedusually between 40-80 mg daily
Limited pharmacokinetic data suggest that a lumbar-cisternal concentration gradient of about 4:1 is established along the neuroaxis during baclofen infusionThis is based upon simultaneous CSF sampling via cisternal and lumbar tap in 5 patients receiving continuous baclofen infusion at the lumbar level at doses associated with therapeutic efficacythe interpatient variability was greatThe gradient was not altered by position.
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