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In patints with ankylosing spondylitis, toicoxib 90 mg onc daily povidd signiicant impovmnts in spin pain, inlammation, stinss and unction. Th clinical bnit toicoxib was obsvd as aly as th scond day thapy at initiation tatmnt and was maintaind thoughout th 52-wk tatmnt piod. In a scond study valuating th 60 mg dos compad tth 90 mg dos, toicoxib 60 mg daily and 90 mg daily dmonstatd simila icacy compad tnapoxn 1,000 mg daily. Among inadquat sponds t60 mg daily 6 wks, dos scalation t90 mg daily impovd spinal pain intnsity sc(0-100 mm visual analogu scal) compad tcontinuing on 60 mg daily, with an avag impovmnt -2.70 mm (95% CI: -4.88 mm, -0.52 mm).
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B a man a non-pgnant, non-lactating woman 18 yas and old. Womn childbaing potntial should b willing tus an accptabl bith contol mthod (at th invstigato’s disction) duing th study tavoid pgnancy. Hav voluntaily povidd wittn inomd consnt. B abl tspak, ad, wit, and undstand nglish, undstand th consnt om, complt study latd pocdus, and communicat with th study sta. Hav a clinical diagnosis PHN by histoy objctiv indings in th opinion th Invstigata minimum 6 months. I th patint pool nds tb xpandd toth nuopathic conditions, patints must mt th sam citia patints with PHN and in addition must hav a clinical diagnosis piphal diabtic nuopathy (PDN), idiopathic snsoy nuopathy (ISN) small ib pdominant nuopathy (SN) by histoy clinical indings in th opinion th invstigata minimum 6 months. Hav a pain intnsity scavaging ?3 on a 0-10 NS avag daily call ov past 24 hous (at Visit 1) B, in th opinion th invstigato, in gnally good halth (oth than PHN) at scning, basd upon th sults a mdical histoy, physical xamination and laboatoy analysis.
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