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Celebrex may also cause stomach or intestinal bleedingwhich can be fatalThese conditions can occur without warning while you are using Celebrexespecially in older adults.
Clinical trials of other COX-2 selective and non-selective NSAIDs of up to three-years duration have shown an increased risk of serious cardiovascular thrombotic eventsmyocardial infarctionand strokewhich can be fatalAs a resultall NSAIDs are considered potentially associated with this risk.
Correct volume status in dehydrated or hypovolemic patients prior to initiating CELEBREXMonitor renal function in patients with renal or hepatic impairmentheart failuredehydrationor hypovolemia during use of CELEBREXsee DRUG INTERACTIONSAvoid the use of CELEBREX in patients with advanced renal disease unless the benefits are expected to outweigh the risk of worsening renal functionIf CELEBREX is used in patients with advanced renal diseasemonitor patients for signs of worsening renal function.
Consider alternative management in patients who are poor CYP2C9 metabolizers.
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