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Parenteral25 mg IV or IMfollowed by close observation for responseThis dose may be repeated within 2 hours if neededOral therapy should be started as soon as feasible if continued medication is required.
Treatment of overdosage is essentially symptomatic and supportiveOnly in cases of extreme overdosage or individual sensitivity do vital signsincluding respirationpulseblood pressuretemperatureand EKGneed to be monitoredActivated charcoal orally or by lavage may be givenor sodium or magnesium sulfate orally as a catharticAttention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilationDiazepam may be used to control convulsionsAcidosis and electrolyte losses should be correctedNote that any depressant effects of promethazine HCl are not reversed by naloxoneAvoid analeptics which may cause convulsions.
Anaphylactic reactionsas adjunctive therapy to epinephrine and other standard measuresafter the acute manifestations have been controlled.
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