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Closely monitor INR when starting or stopping any antibiotic or antifungal in patients taking warfarin.
There have been reports of changes in INR in patients taking warfarin and antibiotics or antifungalsbut clinical pharmacokinetic studies have not shown consistent effects of these agents on plasma concentrations of warfarin.
COUMADIN . is prescription medicine used to treat blood clots and to lower the chance of blood clots forming in your bodyBlood clots can cause a strokeheart attackor other serious conditions if they form in the legs or lungs.
Consult the labeling of all concurrently used drugs to obtain further information about interactions with COUMADIN or adverse reactions pertaining to bleeding.
COUMADIN has no direct effect on an established thrombusnor does it reverse ischemic tissue damageOnce a thrombus has occurredhoweverthe goals of anticoagulant treatment are to prevent further extension of the formed clot and to prevent secondary thromboembolic complications that may result in serious and possibly fatal sequelae.
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