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The following should be kept in mind when considering alternate day therapy:
Take prednisone exactly as prescribed by your doctorFollow the directions on your prescription label carefully.
The rationale for this treatment schedule is based on two major premisesathe anti-inflammatory or therapeutic effect of corticoids persists longer than their physical presence and metabolic effects andbadministration of the corticosteroid every other morning allows for re-establishment of more nearly normal hypothalamic-pituitary-adrenalHPAactivity on the off-steroid day.
Cardiac and renal problemsPrednisone can increase blood pressurecause water and sodium retentionand increase potassium and calcium excretionTell your doctor if you have a history of heart or kidney disease.
2ADT is a therapeutic technique primarily designed for patients in whom long-term pharmacologic corticoid therapy is anticipated.
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