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Known to have hypersensitivitye.ganaphylaxisto ondansetron or any of the components of the formulationsee ADVERSE REACTIONSreceiving concomitant apomorphine due to . the risk of profound hypotension and loss of consciousness.
You should not use this medication if you are allergic to ondansetron or to similar medicines such as dolasetronAnzemetgranisetronKytrilor palonosetronAloxiDo not take ondansetron if you are also using apomorphineApokyn
ZOFRAN does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracuriumInteractions with general or local anesthetics have not been studied.
Pediatric cases consistent with serotonin syndrome have been reported after inadvertent oral overdoses of ondansetronexceeding estimated ingestion of 5 mg per kgin young childrenReported symptoms included somnolenceagitationtachycardiatachypneahypertensionflushingmydriasisdiaphoresismyoclonic movementshorizontal nystagmushyperreflexiaand seizurePatients required supportive careincluding intubation in some caseswith complete recovery without sequelae within 1 to 2 days.
Although ZofranZuplenz and the generic ondansetron are FDA-approved only for use in treating nausea and vomiting after chemotherapy or radiotherapy or after surgerymany doctors prescribe them for off-label usesincluding treatment of morning sickness in expectant mothers.
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