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Terazosin tablets have a major influence on the ability to drive and use machinesDizzinesslight-headedness or drowsiness may occur with the initial dose or in association with missed doses and subsequent reinitiation of Hytrin therapyPatients should be cautioned about these possible adverse effects and the circumstances in which they may occur and advised to avoid driving or hazardous tasks for approximately 12 hours after initial dose or when the dose is increased.
Orally administered Hytrin is indicated in adults for the treatment of mild to moderate hypertensionIt may be used in combination with thiazide diuretics and/or other antihypertensive drugs or as sole therapy where other agents are inappropriate or ineffectiveThe hypotensive effect is most pronounced on the diastolic pressureAlthough the exact mechanism of the hypotensive action of terazosin is not establishedthe relaxation of peripheral blood vessels appears to be produced mainly by competitive antagonism of post-synaptic alpha-1-adrenoceptorsHytrin usually produces an initial gradual decrease in blood pressure followed by a sustained antihypertensive action.
In three placebo-controlled BPH studies 12and 3see CLINICAL PHARMACOLOGYthe incidence of postural hypotension in the terazosin treated patients was 5.15.2and 3.7respectively.
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