The incidence of hepatotoxicity is lower in patients receiving isoniazid for prophylaxis than in those receiving treatment for active disease.
Information about Isoniazid
If you experience any of the following symptoms or those listed in the IMPORTANT WARNING sectioncall your doctor immediately:
Avoid alcohol while taking isoniazidAlcohol may increase the risk of damage to the liver during isoniazid treatment.
It should best be taken 1 hour beforeor 2 hours after a mealIf taken with a meal . gastro-intestinal irritation will be lessbut absorption of the drug may then be impaired.
Nausea/vomiting or stomach upset may occurIf any of these effects persist or worsentell your doctor or pharmacist promptly.
Adults and children5 mg/kgmaximum 300 mgdaily or 15 mg/kg two or three times weekly.
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isoflurane major anesthetic requirements may be increased for isoflurane with concomitant use of isoniazid, inh.var 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