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Methylprednisolone acetatea slightly soluble ester of methylprednisoloneis capable of producing a more prolonged local anti-inflammatory effect than equimolar doses of hydrocortisone acetateFollowing intrasynovial injectionrelief from pain may be experienced within 12 to 24 hoursThe duration of relief variesbut averages three to four weekswith a range of one to five or more weeksInjections of methylprednisolone acetate have been well toleratedIntrasynovialintra-articularinjections may occasionally result in an increased localized inflammatory response.
Frequency not reportedCushingoid statehirsutismsecondary adrenocortical and pituitary unresponsivenessparticularly in times of stressas in traumasurgeryor illnessmoon faceRef]
Frequency not reportedAcneallergic dermatitiscutaneous and subcutaneous atrophydry scaly skinecchymosispetechiaeerythemahyperpigmentationhypopigmentationimpaired wound healingincreased sweatingrashsterile abscessstriaesuppressed reactions to skin teststhin fragile skinthinning scalp hairurticariahypertrichosisangioedemaskin atrophyhyperhidrosispruritusRef]
MEDROL Tablets like prednisoloneare contraindicated in animals with arrested tuberculosispeptic ulceracute psychosesand Cushingoid syndromeThe presence of diabetesosteoporosischronic psychotic reactionspredisposition to thrombophlebitishypertensioncongestive heart failurerenal insufficiencyand active tuberculosis necessitates carefully controlled useSome of the above conditions occur only rarely in dogs and cats but should be kept in mind.
Other Conditions In certain conditions where it is desired to reduce inflammationvascularizationfibroblastic infiltrationand scar tissuethe use of DEPO-MEDROL should be consideredSnakebite of dogs also is an indication for the use of this suspension because of its anti-toxemicanti-shockand anti-inflammatory activityIt is particularly effective in reducing swelling and preventing sloughingIts employment in the treatment of such conditions is recommended as a supportive measure to standard procedures and timehonored treatments and will give comfort to the animal and hasten complete recovery.
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