Some of the most common medications in these categories are prednisone, prednisolone, decadron, deltasone, dexamethasone, medrol, orasone, pediapred, and prelone.
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The diurnal rhythm of the HPA axis is lost in Cushing’s diseasea syndrome of adrenocortical hyperfunction characterized by obesity with centripetal fat distributionthinning of the skin with easy bruisabilitymuscle wasting with weaknesshypertensionlatent diabetesosteoporosiselectrolyte imbalanceetcThe same clinical findings of hyperadrenocorticism may be noted during the long-term pharmacologic dose corticoid therapy administered in conventional daily divided dosesIt would appearthenthat a disturbance in the diurnal cycle with maintenance of elevated corticoid values during the night may play a significant role in the development of undesirable corticoid effectsEscape from these constantly elevated plasma levels for even short periods of time may be instrumental in protecting against undesirable pharmacologic effects.
You should not stop using prednisolone suddenlyFollow your doctor’s instructions about tapering your dose.
Have had an allergic reaction to prednisolone or any other medicine have an infectionincluding eye infectionsare trying to get pregnantare already pregnant or you are breastfeeding have recently been in contact with someone with shingleschickenpox or measlesunless you are sure you are immune to these infectionshave recently hador are about to haveany vaccinations.
See your doctor immediately or go to the emergency department of your nearest hospital if you experience any of these serious side effects:
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