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Fluoxetine has not been systematically studiedin animals or humansfor its potential for abusetoleranceor physical dependenceWhile the pre-marketing clinical experience with fluoxetine did not reveal any tendency for a withdrawal syndrome or any drug seeking behaviorthese observations were not systematic and it is not possible to predict on the basis of this limited experience the extent to which a CNS active drug will be misuseddivertedand/or abused once marketedConsequentlyphysicians should carefully evaluate patients for history of drug abuse and follow such patients closelyobserving them for signs of misuse or abuse of SARAFEMfor exampledevelopment of toleranceincrementation of dosedrug-seeking behavior
There have been rare postmarketing reports of serotonin syndrome with use of an SSRI and a triptanIf concomitant treatment of SARAFEM with a triptan is clinically warrantedcareful observation of the patient is advisedparticularly during treatment initiation and dose increasessee WARNINGS AND PRECAUTIONS
As with other SSRIsdecreased weight gain has been observed in association with the use of fluoxetine in children and adolescent patientsAfter 19 weeks of treatment in a clinical trialpediatric subjects treated with fluoxetine gained an average of 1.1 cm less in height and 1.1 kg less in weight than subjects treated with placeboIn additionfluoxetine treatment was associated with a decrease in alkaline phosphatase levelsThe safety of fluoxetine treatment for pediatric patients has not been systematically assessed for chronic treatment longer than several months in durationIn particularthere are no studies that directly evaluate the longer-term effects of fluoxetine on the growthdevelopment and maturation of children and adolescent patientsThereforeheight and weight should be monitored periodically in pediatric patients receiving fluoxetinesee WARNINGS AND PRECAUTIONS
The liquid form of this medication contains alcoholCaution is advised if you have diabetesalcohol dependenceor liver diseaseSome medicationssuch as metronidazoledisulfiramcan cause a serious reaction when combined with alcoholAsk your doctor or pharmacist about using this product safely.
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