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Clopidogrel must be metabolized by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregationThe active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphateADPto its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complexthereby inhibiting platelet aggregationThis action is irreversibleConsequentlyplatelets exposed to clopidogrel’s active metabolite are affected for the remainder of their lifespanabout 7 to 10 daysPlatelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.
Figure 3Hazard Ratio for Patient Baseline Characteristics and On-Study Concomitant Medications/Interventions for the CURE Studycontinued)
Tell your doctor about all the medicines you takeincluding prescriptionnonprescription medicinesvitamins and herbal supplements.
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plavix generic name clopidogrel is an oral anti-platelet drug that prevents the risk of heart attack as it discourages the formation of clots thereby improving the blood flow to the different parts of the body including the heart and brain.var 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