Le reazioni avverse in un processo di manutenzione di 1 anno e una prova bpco di 12 settimane con zyban erano quantitativamente e qualitativamente simili a quelli osservati negli studi doseresponse e di confronto.
Information about Zyban
A tabletThe active ingredient in Zyban is a drug called bupropion hydrochloride.
In the literature it has been shown that medications that inhibit CYP2D6 may lead to reduced concentrations of endoxifen which is the active metabolite of tamoxifenTherefore the use of bupropionwhich is an inhibitor of CYP2D6should whenever possible be avoided during tamoxifen treatmentsee section 4.5
This medication belongs to a class of medications known as antidepressantsIt is not known exactly how bupropion works to reduce smoking urgesIt may work by restoring the balance of certain natural chemicalsneurotransmittersin the brain.
Since bupropion is extensively metabolisedcaution is advised when bupropion is co-administered with . medicinal products known to induce metabolisme.gcarbamazepinephenytoinritonavirefavirenzor inhibit metabolisme.gvalproateas these may affect its clinical efficacy and safety.
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