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DisclaimerHealthline has made every effort to make certain that all information is factually correctcomprehensiveand up-to-dateHoweverthisarticle should not be used as a substitute for the knowledge and expertise of a licensed healthcare professionalYou should always consult your doctor or other healthcare professional before taking any medicationThe drug information contained herein is subject to change and is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsThe absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safeeffectiveor appropriate for all patients or all specific uses.
There are no data that support specific guidance for dosage adjustment in patients with hepatic impairmentClose monitoring of hematologic parameters is advised in these patients.
Secondary MalignanciesThere is a very low risk of developing leukemia or skin cancer due to treatment with this medicationwhich can occur many years after treatmentThis is most often associated with long-term treatmentRadiation RecallRadiation recall is when the administration of a medication causes a skin reaction that looks like a sunburnrednessswellingsorenesspeeling skinin areas where radiation was previously givenNotify your oncology team if you notice this side effectTreatment can include topical steroid ointments and a delay in your next chemotherapy doseTumor Lysis SyndromeIf there are a large amount of tumor cells in your body prior to treatmentyou are at risk for tumor lysis syndromeThis happens when the tumor cells die too quickly and their waste overwhelms the bodyYou may be given a medicationallopurinoland IV fluids to help prevent thisIf you experience nauseavomitingdiarrhea or become lethargicdrowsysluggishnotify your oncology team right awayTLS can affect your kidney functionYour provider will monitor your kidney function with blood workNotify your provider if you have little or no urine outputMucositisCertain cancer treatments can cause sores or soreness in your mouth and/or throatNotify your oncology care team ifyour mouthtongueinside of your cheek or throat becomes whiteulcerated or painfulPerforming regular mouth care can help prevent or manage mouth soresIf mouth sores become painfulyour doctor or nurse can recommend a pain relieverLiver ToxicityThis medication can cause liver toxicitywhich your oncology care team may monitor for using blood tests called liver function testsNotify your healthcare provider if you notice yellowing of the skin or eyesyour urine appears dark or brownor you have pain in your abdomenas these can be signs of liver toxicity.
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