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Copyright 1996-2013 Cerner MultumIncVersion10.02Revision date3/12/2012.
This list is not completeOther drugs may interact with hydrochlorothiazide and losartanincluding prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed in this medication guide.
ABrand-name prescription drugs are protected under patentWhen the patent expiresother drug companies can start manufacturing and selling a generic form of the drugThe last patent for Hyzaarlosartan/hydrochlorothiazideexpired on April 62010Numerous generic drug manufacturers obtained approval for their losartan/hydrochlorothiazide products on that same dayso generic products should be available shortlyConsult your local pharmacist for more specific information on generic availability.
Fetal toxicity may developdiscontinue if pregnancy is detectedCorrect salt/volume depletion before starting therapyor . reduce initial doseHepatic impairmentinitial therapy not recommendedSevere renal impairmentCrClsupplementsKsparing diureticsKcontaining salt substitutesDual inhibition of the renin-angiotensin system with ARBsACEIsor aliskiren may increase risk of hypotensionhyperkalemiarenal function changesmonitor closelyAvoid concomitant aliskiren in renal impairmentCrCl.
Hydrochlorothiazide can pass into breast milk and may cause side effects in the nursing babyYou should not breast-feed while using Hyzaar.
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