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Increased prothrombin timewith or without clinical bleedinghas been reported when cefixime is administered concomitantly.
If CDAD is suspected or confirmedongoing antibiotic use not directed against Cdifficile may need to be discontinuedAppropriate fluid and electrolyte managementprotein supplementationantibiotic treatment of Cdifficileand surgical evaluation should be instituted as clinically indicated.
Cdifficile produces toxins A and B which contribute to the development of CDADHypertoxin producing isolates of Cdifficile cause increased morbidity and mortalityas these infections can be refractory to antimicrobial therapy and may require colectomyCDAD must be considered in all patients who present with diarrhea following antibiotic useCareful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
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