A total of 4 , 8 and 11 of patients discontinued therapy due to intolerance in the placebo, depakote, and lithium carbonate groups, respectively.
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These total daily doses of depakote cannot be directly converted to an 8 to 20 higher total daily dose of depakote er because the required dosing strengths of depakote er are not available.
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As depakote er dosage is titrated upward, blood concentrations of phenobarbital and or phenytoin may be affected seedrug interactions 7.
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