Pubmed 20120834 goetz mp tamoxifen, endoxifen, and cyp2d6 the rules for evaluating a predictive factor.
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In the anastrozole adjuvant trial, co-administration of anastrozole and nolvadex in breast cancer patients reduced anastrozole plasma concentration by 27 compared to those achieved with anastrozole alone; however, the coadministration did not affect the pharmacokinetics of tamoxifen or n-desmethyltamoxifen see precautions -drug interactions .
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At least one other trial of extended tamoxifen therapy reached the opposite conclusion to the atlas trial.
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There may also be additional benefits from the cholesterol-lowering effect of tamoxifen with reduction in frequency of death from myocardial infarction and from the significant protection it appears to offer against postmenopausal bone loss.
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