Minocycline, a second generation tetracycline-based molecule, is a highly lipophilic compound and penetrates the brain blood barrier easily 16 , 41 .
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Hepatotoxicity may occur in pregnant womenparticularly after IV administration and in those with azotemia or pyelonephritisTaking high doses during pregnancy can lead to fatty degeneration of the liverwhich may be fatal.
Tetracycline may also be used for other purposes not listed in this medication guide.
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