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Seek medical treatment if you have symptoms of a serious drug reaction that can affect many parts of your bodySymptoms may includeskin rashfeverswollen glandsflu-like symptomsunusual bruisingor jaundiceyellowing of your skin or eyes
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMShas been reported . in association with administration of antipsychotic drugsincluding olanzapineClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental status and evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmiaAdditional signs may include elevated creatinine phosphokinasemyoglobinuriarhabdomyolysisand acute renal failure.
The conditions and duration of treatment with olanzapine varied greatly and includedin overlapping categoriesopen-label and double-blind phases of studiesinpatients and outpatientsfixed-dose and dose-titration studiesand short-term or longer-term exposureAdverse reactions were assessed by collecting adverse reactionsresults of physical examinationsvital signsweightslaboratory analytesECGschest x-raysand results of ophthalmologic examinations.
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