Start symbyax at 3 mg 25 mg or 6 mg 25 mg in patients with a predisposition to hypotensive reactions, patients with hepatic impairment, or patients who exhibit a combination of factors that may slow the metabolism of symbyax female gender, geriatric age, nonsmoking status or those patients who may be pharmacodynamically sensitive to olanzapine.
Information about Olanzapine
CarbamazepineTegretolcan reduce blood concentrations of olanzapinepossibly necessitating higher doses of olanzapineOther drugs that may also reduce blood levels of olanzapine are omeprazolePrilosecand rifampin.
Examples of drugs that can cause interactions with olanzapine are listed below.
Transientasymptomatic elevations of hepatic aminotransferasesALTAST have been seen commonlyespecially in early treatmentCaution should be exercised and follow-up organised in patients with elevated ALT and/or ASTin patients with signs and symptoms of hepatic impairmentin patients with pre-existing conditions associated with limited hepatic functional reserveand in patients who are being treated with potentially hepatotoxic medicinesIn cases where hepatitisincluding hepatocellularcholestatic or mixed liver injuryhas been diagnosedolanzapine treatment should be discontinued.
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